Systems Biology

Lecture on Systems Biology, WS 2003/04

Systems biology is a new field in biology where organisms and biological processes are quantitatively analysed in terms of the components and their interaction and described at a system level in a framework of mathematical models.

• Introduction to biological reactions, enzyme kinetics
• Cellular networks of material, energy, and information flow
• Graph theory for network analysis
• Construction of metabolic and genetic networks based on genomic and functional genomic data
• Structural analysis of large scale metabolic networks
• Metabolic flux and control analysis
• Analysis and modeing of genetic networks
• Nonlinear system behavior and dynamic modelling
• Phase-space analysis of dynamical systems
• Oscillations, attractors
• Solving ordinary differential equations
• Stochastic modelling
• Spatial modelling of biological phenomena
• Diffusion and Transport inside and across cells
• Whole-cell modelling
• Application example: Metabolic engineering

Lecturers

Privatdozent Dr. An-Ping Zeng
Privatdozent Dr. Jörg R. Weimar

Contact

Jörg R. Weimar
Institut für Wissenschaftliches Rechnen
TU Braunschweig
E-mail: J.Weimar (Klammeraffe) tu-bs.de

PD Dr. An-Ping Zeng
Abteilung Genomanalyse, Gesellschaft für Biotechnologische Forschung (GBF)
anping.zeng (atsign) gbf.de

Place and Time

Mondays 15:45 - 17:15
Room BZ 046, Biozentrum, TU Braunschweig

Start

Monday, 27. Oktober 2003

Target Audience

Students of Biology, Microbiology, Biotechnology/Bioengineering, CSE, Computer Science

Prerequisites

Interest, basic calculus and biochemistry

• Molecular Cell Biology by Harvey Lodish, Arnold Berk, S. L. Zipursky
• The Regulation of Cellular Systems by Reinhart Heinrich, Stefan Schuster

Slides from some lectures (get the password in class)